Aesthetic Medicine Practice
Doctor Dubois

2 square Lafayette
49000 Angers
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Adresse du cabinet de médecine esthétique à Angers Contact us

What is cellulite?

Hydrolipodystrophy is an increase in body fat in the hypodermis with water retention and localized preadipocyte fibrosis. It is known as "cellulitis", which gives an appearance of dimpled or "orange peel" skin in the majority of women. It is mostly an issue of aesthetic medicine, but when accompanied by excessive weight, it becomes a problem of public health.

In common parlance, hydrolipodystrophy is called cellulite. It is a gynoid lipodystrophy (abnormal fat tissue with gynoid distribution), thus particular to women. This hypertrophy of adipose tissue is highly localized and may be seen even in very thin women. This clustering is often located around the hips or on the stomach, buttocks and thighs. 90% of women are affected by this unsightly condition that may begin at puberty. Only 2% of men are affected.


Where does cellulite come from?

It is linked to certain factors:
- Genetics: affects primarily women
- Hormonal: oral contraceptives, corticosteroids, age
- Vascular: factors adding to venous stasis, venous insufficiency of lower limbs
- Metabolic and nutritional
- Lifestyle: smoking, obesity, a sedentary lifestyle (no exercise), binge eating

How best to treat it?

Mesotherapy provides a scientifically proven answer/response/relief to patients subject to the health problems and related social constraints:

  • Meso-drainage uses 3 products that improve local circulation, facilitating the elimination of fat by literally emptying the fat cells.
    Hypo-osmolar meso-dissolution completes the treatment, especially in localized areas: abdomen, hips, inner thighs and knees, buttocks... Meso-dissolution destroys fat cells.
  • The 2 methods are complementary and there are a number of different protocols, such as the 3-6-3 pattern (3 meso-drainage sessions, then 6 meso-dissolution sessions followed by 3 more meso-drainage sessions)
  • A sensible diet is indispensable, but not necessarily a restrictive one.  We encourage positive, health-enhancing nutrition.

  • Regular physical activity optimises results.



What is Meso-dissolution?

Meso-dissolution derives from “lipotomy”, which is a method used to break down fat cells by way of hyper-hydration combined with the effect of osmotic pressure differentials.

We became intrigued by American studies on the treatment of cellulite using hypo-osmolar solutes. We decided to associate the process with mesotherapy, adapting techniques and solution mixtures in an attempt to obtain the most effective synergy possible. Some of the most interesting work being done in the United States has been by Dr. Steven Hoefflin, Director of the Plastic Surgery Department at the University of California’s School of Medicine in Los Angeles (UCLA). We note his "Pharmacological Lipodissolution Hypotonia," a study published in 1997.

The basic principle is to inject a hypo-osmolar and circulatory solute into the deep, fatty intradermal tissue of the cellulite zone. The differential between the physiological osmolarity (300 mOsm / l) and hypo-osmolarity of the solute (90 to 120 mOsm / l) causes adipocytes (fat cells) to swell and burst.

In order to act upon both the dermis (an anti-edematous effect) and hypodermis (a lipolytic effect), we use a combination of mesotherapy products in a hypotonic solution, as per national protocol validated during mesotherapy training at La Pitie-Salpetriere Hospital’s University of Medicine, in Paris, notably in 2008.

Meso-dissolution is a new mesotherapy treatment for cellulite, one that widens the range of indications. It has been performed for over 6 years, on over 6000 patients, resulting in a large body of clinical, biological and ultrasound experience. We are finally able to treat fibrous cellulite via the lipolytic (fat destroying) action of this new technique.

Its triple action effect can treat edematous, fibrous and adipose cellulite tissues:

- Lipolysis and defibrosis (Mesodissolution ®)
- Circulatory anti-edema (Mésodrainage)
The basic technique is enhanced by virtue of several products whose active ingredients each perform on different components of the dermis.

Results clearly demonstrate that the technique is effective on the skin’s appearance as well as the volume of treated areas, that it is well tolerated. Both patients and physicians expectations are generally satisfied.

The Method
Products are injected with a fine needle into the surface areas to be treated, most commonly  the abdomen, hips, buttocks and thighs:

- Either using an electronic injection gun, which delivers SuperficiaI Intra Dermo micro-capsules in a regular and well-calibrated manner, causing very little discomfort,
- Or using the manual method, whereby the syringe is held while injecting the micro-doses, a process better suited to treating skin irregularities,
- Or using the IntraEpidermal (IED) technique, which deposits a very thin layer of product upon the skin – an even gentler process.

Treatment schedule:
1 session per week, with a total of anywhere between 8 and 12 sessions depending on the desired results.

Length of a mesotherapy session:

- Mesodraine (3 products): 15 min
- Mesodissolution (5 products): 25 min

However, a new patient’s first session — including a clinical examination, skin and diet assessment, biometrics and suggested care — lasts 1 hour. Actual treatment can begin upon the second visit.

resultcelluliteThe benefits of comprehensive care:
Some patients also needs to lose weight, though not all. Every kilo lost represents a reduction of 1 cm around the belly and hips; for example, when 8 kg have been lost, so have 8 cm, which can represent 2 clothing sizes (a size 44 becomes a size 40).

Session Pricing:
The cost of a meso-drainage session is 55 €, 70 € for a mesocellulite session.